Cuttlefish is a good source of protein, essential amino acids and several vitamins and minerals. A 3-ounce serving of cuttlefish prepared using a moist cooking method has 134 calories and over 25 percent of your daily value of sodium, but almost no fat, saturated fat or carbohydrates. Because cuttlefish is extremely low in carbohydrates, but offers significant health benefits, it's an excellent choice for people following low-carbohydrate, high-protein diets. Cuttlefish can be fried, braised, broiled, grilled, sautéed and cooked in stews and soups. Grilled chunks of cuttlefish are often used in tapas recipes, pastas and salads. To reduce the amount of fat and cholesterol in your cuttlefish recipes, avoid frying it.